Non-Hodgkin's lymphoma is a rare but serious condition that has been linked to the use of dermal fillers. In one case, a patient with a history of foreign body injection developed lymphoma, indicating that prolonged chronic inflammation resulting from injections of dermal fillers can trigger the development of this type of cancer. The injection of dermal fillers breaks the skin barrier, posing a risk of infection. This can manifest as acute inflammation or abscesses at the injection site, or as chronic late-onset infections, which usually develop two or more weeks after initial treatment.
Differential diagnosis of cellulitis versus pure inflammation is often a clinical challenge in the absence of fever or abscess formation and may require aspiration, culture and blood tests to confirm etiology. Systemic steroids, although indicated to calm inflammation, are contraindicated in cases of infection. The infection can be treated with oral antibiotics, which exert immunomodulatory and anti-inflammatory effects. For further treatment, the possibility of using hyaluronidase, intravenous antibiotics, laser or surgical drainage of the abscess may be considered. Dermal fillers are popular for cosmetic purposes such as reducing wrinkles and folds around the forehead, eyes, mouth and nose, and for lip augmentation.
Knowledge of optimal placement and injection depth is critical to the aesthetic success of dermal fillers. The reversibility of hyaluronic acid (HA) fillers is a powerful advantage, since most of the complications induced by these fillers can be addressed. The 10-point plan (10PP) is a systematic and effective strategy aimed at reducing the risk of dermal filler complications. This includes proper patient selection and assessment, appropriate product selection and preparation, correct injection technique and depth, appropriate post-treatment care and follow-up, and proper documentation. It's important to note that non-surgical treatments such as Botox or dermal fillers will not provide facelift results. In conclusion, doctors should be aware that prolonged chronic inflammation resulting from injections of dermal fillers can trigger the development of lymphoma.
Patients should also be aware that there are risks associated with dermal filler treatments and should consult with their doctor before undergoing any procedure.